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The demographics of the included studies included author, study, publication year, study duration, study arms, sample size, average age, sex ratio, diabetes duration, HbA1c and body weight (Table 1)

One of the key mechanisms underlying the dark and shrunken morphology of granule cells in the DG during epileptic episodes is excitotoxicity, primarily mediated by excessive glutamate release (Wang and Qin, 2010)